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HCCDB: Hepatocellular Carcinoma Expression Atlas

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Current Version
  Release 1.21
  (2016/11/02)

Number of Datasets
  mRNA: 13
  miRNA: 4

Number of Samples
  HCC: 2109
  Adjacent: 1277
  Healthy: 18
  Cirrhotic: 40

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 Hepatocellular carcinoma (HCC), the major primary liver cancer, is one of the most common cancer type world-wide. Current studies show that HCCs is highly genetic heterogeneous. Large-scale molecular profiles are crucial for identifying the altered molecular networks, diverse biomarkers and  molecule-based subtypes of HCCs.

HCCDB aims at collecting large-scale gene expression profiles (in current release) and other molecular data of HCC clinical samples. The database search engine provides gene centered meta-data interface: it visualizes the expression details and prognostic values of each gene. The database also provides basic data analysis tools, including differential analysis and survival analysis. HCCDB should be a useful resource for HCC research.

NOTE: Please use Google Chrome (Recommended!) / Fifefox / Internet Explorer 11 for normal display!

NOTE: Please cite HCCDB if you find it useful in your publications!
DATASET ANALYSIS
HCCDB-1

  Source: GSE22058
  Sample: Adjacent 97; HCC 100; Paired
  Platform: mRNA array, miRNA array

Diff_Analysis: HCC/Adjacent (mRNA)

Diff_Analysis: HCC/Adjacent (miRNA)
HCCDB-3

  Source: GSE25097
  Sample: Healthy: 6; Cirrhotic: 40; Adjacent: 243; HCC: 268
  Platform: mRNA array

Diff_Analysis: Adjacent/HCC

Diff_Analysis: Healthy/Cirrhotic/Adjacent/HCC
HCCDB-4

  Source: GSE36376
  Sample: Adjacent: 193; HCC: 240
  Platform: mRNA array

Diff_Analysis: Adjacent/HCC

Diff_Analysis: AJCC_Stage in HCC
HCCDB-5

  Source: GSE14520 (GPL571 Subset)
  Sample: Healthy: 2; Adjacent: 19; HCC: 22; Paired (Subset)
  Platform: mRNA array

Diff_Analysis: Adjacent/HCC

Survival_Analysis: HCC

Survival_Analysis: Adjacent
HCCDB-6

  Source: GSE14520 (GPL3721 Subset)
  Sample: Adjacent: 220; HCC: 225; Paired (Subset)
  Platform: mRNA

Diff_Analysis: Adjacent/HCC

Survival_Analysis: HCC

Survival_Analysis: Adjacent
HCCDB-7

  Source: GSE10143
  Sample: Adjacent: 82; HCC: 80; Paired (Subset); FFPE
  Platform: mRNA array

Diff_Analysis: Adjacent/HCC

Survival_Analysis: HCC

Survival_Analysis: Adjacent
HCCDB-8

  Source: GSE9843, GSE20594
  Sample: HCC: 91
  Platform: mRNA array, miRNA array

Diff_Analysis: Vascular_Invasion in HCC (mRNA)

Diff_Analysis: Vascular_Invasion in HCC (miRNA)

Diff_Analysis: BCLC_Stage in HCC (mRNA)

Diff_Analysis: BCLC_Stage in HCC (miRNA)
HCCDB-9

  Source: GSE19977
  Sample: HCC: 164
  Platform: mRNA array

 Diff_Analysis: Vascular_Invasion in HCC (mRNA)
HCCDB-10

  Source: GSE10694
  Sample: Healthy: 10; Adjacent: 78; HCC: 78; Paired
  Platform: miRNA array

Diff_Analysis: Healthy/Adjacent/HCC

Diff_Analysis: Adjacent/HCC (Paired)

Diff_Analysis: Cirrhosis in HCC

Diff_Analysis: Metastasis in HCC

Diff_Analysis: Pathologic_Stage in HCC

Survival_Analysis: HCC

Survival_Analysis: Adjacent
HCCDB-11

  Source: GSE46444
  Sample: Adjacent: 48; HCC: 88; FFPE
  Platform: mRNA array

 Diff_Analysis: Adjacent/HCC
HCCDB-12

  Source: GSE54236
  Sample: Adjacent: 80; HCC: 81; Paired
  Platform: mRNA array

Diff_Analysis: Adjacent/HCC

Survival_Analysis: Tumor_doubling_time in HCC

Survival_Analysis: Tumor_doubling_time in Adjacent
HCCDB-13

  Source: GSE63898
  Sample: Adjacent: 168; HCC: 228
  Platform: mRNA array

Diff_Analysis: Adjacent/HCC

Diff_Analysis: BCLC_Stage in HCC
HCCDB-14

  Source: GSE43619
  Sample: HCC: 88
  Platform: mRNA array

 Not Applicable
HCCDB-15

  Source: TCGA-LIHC Hepatocellular Carcinoma
  Sample: Adjacent: 49; HCC: 356; Paired (Subset)
  Platform: RNA-seq, miRNA-seq

 Diff_Analysis: Adjacent/HCC (mRNA)

Diff_Analysis: AJCC_Stage in HCC (mRNA)

Diff_Analysis: Vascular_Invasion in HCC (mRNA)

Survival_Analysis: HCC (mRNA)

Survival_Analysis: Adjacent (mRNA)

Diff_Analysis: Adjacent/HCC (miRNA)

Diff_Analysis: AJCC_Stage in HCC (miRNA)

Diff_Analysis: Vascular_Invasion in HCC (miRNA)

Survival_Analysis: HCC (miRNA)

Survival_Analysis: Adjacent (miRNA)
TNLIST Bioinformatics Division, Tsinghua University, Beijing 100084, China                                                                    Homepage for Gu's Lab