MicroRNAs (miRNAs), a class of endogenous small regulatory RNAs, play important roles in many biological and physiological processes. Till now, many miRNAs are shown to be functionally related to cancer initiation, development and therapy. To facilitate the study on cancer-related miRNAs, we set up this oncomiRDB database aiming at annotating the experimentally verified oncogenic and tumor-suppressive miRNAs from literature.
This database only collects items having direct functional evidences: 1) the miRNA regulates at least one cancer-related phenotype or cellular process (such as proliferation, apoptosis, migration and invasion, senescence and cell cycle regulation);
or 2) the miRNA directly regulates at least one oncogenic or tumor-suppressive gene verified by luciferase reporter assay. It should be a very useful resource for both the computational analysis and the experimental study on miRNA regulations in cancer.
Citation: Dongfang Wang, Jin Gu#, Ting Wang, Zijian Ding. OncomiRDB: a database for the experimentally verified oncogenic and tumor-suppressive microRNAs. Bioinformatics 2014, 30(15):2237-2238.
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